Archive for the 'BioTech/Life Science' Category

Sep4th2008

Is a Ph.D. Required to be a Biotech Entrepreneur?

Graham Randall is a regular contributor to Startup Houston on the topics of biotech, life sciences and entrepreneurship.

Do you need a Ph.D. to be a Biotech Entrepreneur? This seems to be a popular question these days, even though I think the answer is pretty obvious: No.

There are lots of biotech entrepreneurs out there without Ph.Ds. What really matters is what role you want to play in your startup company. If you want to found a company and be its lead scientist, then obviously a Ph.D. will be required. Not just for the credential, but because it’ll take you several years to acquire the knowledge necessary to do the kind of research that yields results with commercial potential.

But if your intent is to be the founder and general manager of a biotech company, then the value of a Ph.D. is diminished.

Why would you need a Ph.D.?

The knowledge you gain from earning a Ph.D. will help you evaluate technologies. Even when you’re evaluating technologies that aren’t directly in your field of expertise, the critical and analytical skills you learn in acquiring a Ph.D. will help you quickly get up to speed and start asking the right questions.

You’ll also learn some leadership skills while doing your Ph.D. You’ll gain experience giving lectures and communicating your ideas. You’ll learn how to think on your feet and handle tough questions. And from these experiences, you’ll gain some confidence.

The Ph.D. is also a credential that will allow you to apply for grants on your own. Even so, if you’re not the inventor of your technology, then your partner, the inventor, will probably have a Ph.D.

Why don’t you need a Ph.D.?

If your goal isn’t to be the Chief Scientist of a biotech company, then the 4-7 years you spend in a lab trying to get a Ph.D. would be better spent working at a biotech company gaining practical business experience. Working in a company will not only teach you a lot of technical business skills like finance and accounting, you’ll also be exposed to a variety of management styles, team work, project management, quality assurance, manufacturing, regulatory approval, and sales and marketing. This is the experience you’re probably not going to get in the lab, but it’s crucial to starting a company.

Conclusion

No, I don’t think a Ph.D. is required. Getting a Ph.D. is a personal decision. If you feel passionately about science, or if you have a strong personal compulsion to “phinish”, then go get your Ph.D. But if you think it’s only a means to an end, I think your time is better spent getting real world experience. Maybe even get an MBA (which will be the subject of a future post).

Aug15th2008

Why Aren’t There More Prizes in Science?

Graham Randall is a regular contributor to Startup Houston on the topics of biotech, life sciences and entrepreneurship.

Newt Gingrich recently wrote an editorial in the WSJ [subscription required] calling for greater use of prizes to solve the world’s problems. Regardless of what you think about Newt’s politics, it’s difficult to deny that the current grants-based process of funding science isn’t meeting our needs. Grants are too risk-averse and too time-consuming. As a result, the visionary, but risky, experiments that lead to major breakthroughs have difficulty getting funded, and many future scientists are turned off by the prospect of spending a career writing grant applications. The success of the first X-Prize shows that prizes can work and can be much more cost-effective than the grants system.

Gates Dissatisfied With the Conduct of Science

Derek Lowe commented a while back on the dissatisfaction of the Bill & Melinda Gates foundation with the results of their Grand Challenges. These were grants awarded in 2005 to researchers to try to solve the biggest public health problems. Unfortunately, these grants produced no major scientific breakthroughs. So, the Gates Foundation is reissuing the grants, but this time ignoring the so-called “experts” and looking to other fields for ideas.

Derek isn’t surprised that the grants produced no results since the practice of science is so unpredictable. You can’t do science the same way you would build an operating system–set some deadlines, allocate resources, and draw up a Gantt chart.

Still, I’m not certain that the conduct of science wouldn’t benefit from somebody like Bill Gates throwing some money around and imposing some discipline. Science, and in particular academic science, is woefully inefficient. Part of this is because in academia, the worker bees (graduate students) are still learning their craft. But it’s also because, having accepted that science is unpredictable, hardly anyone puts any thought into managing the project. Few scientists even have training in project management. Experiments get done when they get done, and then the scientists move on to the next experiment. Science, today, is too much like a drunk man’s stagger.

What is generally missing is a project manager–someone to drive the schedule and hold the team accountable for meeting deadlines. By deadlines, I’m not suggesting “cure cancer by the end of the semester.” I’m thinking of shorter-term, measurable goals. What can be accomplished this week, this month, and this semester, and how do the results contribute to the ultimate goal? Nobody’s keeping an eye on these little details in an academic lab. Days turn into months which turn into semesters. Graduate students bang their heads against walls pursuing deadends because nobody set a deadline for pulling the plug.

All of this is allowed to go on in academic science because the focus is on the proposals and the subsequent publications, not the actual, real-world-affecting results. Come review time, anybody can say “Look at how productive we were, we published all these articles!” What Gates is realizing is that publications don’t cure diseases.

Prizes would bring the focus back to results–real-world-affecting results.

Gingrich’s Prizes

In Newt’s article, he suggest seven prizes with $2 billion awards for accomplishing the first three and $1 billion for the rest:

1) A low-cost vaccine or preventive intervention for malaria — possibly the single biggest potential improvement in the quality of life in poor tropical countries.

2) A modestly priced, mass-manufacturable hydrogen engine for cars, which would be the biggest single contribution to reducing carbon loading of the atmosphere and reducing subsidies through high oil prices to dictatorships.

3) A cheap method for turning large quantities of seawater into fresh water.

4) A reusable system that could get people into space at 10% of the current cost, thus enabling genuine space tourism and launching an age of exploration.

5) The first privately financed permanent lunar base.

6) A method for reusing nuclear waste to make Yucca Mountain, Nevada unnecessary as a repository.

7) A method of learning math and science that kids like, and that enables us to leapfrog India and China by breaking out of our unionized, bureaucratic curriculum. This would enable us to replace “No Child Left Behind” with a more effective education model that could be called “Every American Gets Ahead.”

This is a good starting point for further discussion, and I’m sure everybody has their own pet cause they believe is worthy of the list. I’d rather see more prizes for addressing disease. I also think Newt’s prizes are too big. There’s no doubt that the person who invents a mass-manufacturable hydrogen engine will make a lot of money just by licensing the technology to automobile manufacturers. So does that challenge also merit a $2 billion award? For $10 million, the X-Prize found a solution to fly us into space, so why should we spend $1 billion to reduce the cost of that trip by 10%?

We should differentiate between the two uses for prizes:

  1. Spur innovation in a potential commercial market. Compel innovators and entrepreneurs to take the next step to commercialize the technology.
  2. Incentivize innovators to develop solutions to problems for which there is no significant ROI. The mainly applies to orphan diseases, like malaria.

and then adjust the size of the prizes accordingly. Curing orphan diseases is going to require big prizes, but prizes designed to spur innovation in a potential commercial market should be just large enough to motivate people to get started–like the $10 million offered for the X-Prize.

So what do you all think? What causes do you think merit prizes? How big should those prizes be? Please leave your ideas in the comments.

Aug8th2008

Houston’s Dearth of Biotech Entrepreneurship

This post comes to us courtesy of Graham Randall, Ph.D., MBA, who has agreed to become a regular contributor to Startup Houston and will write on the topic of biotech, life sciences and entrepreneurship. Graham is a Ph.D. candidate in molecular biophysics at Baylor College of Medicine where he was a fellow of the W.M. Keck Center for Computational Biology and a recipient of the prestigious John J. Trentin Scholarship Award. His research focuses on the effects of DNA topology on protein-DNA interactions. Prior to graduate school, Graham spent eight years in Silicon Valley as a software architect working for several startup companies, including Tellme Networks. He has an MBA from Rice University and a B.A. in applied mathematics from the University of California at Berkeley. Graham also writes two other blogs: Driving While Texan and Two Randalls.

Houston lags the major biotech clusters

A lot of energy has been spent in the last 10 years trying to figure out why Houston, with all the research conducted in its world-class medical center, hadn’t spawned more biotech startups. Houston lagged behind the major biotech clusters-San Francisco, San Diego, and Boston-in the number of biotech employees (~10,000 vs. 30,000-40,000), the number of VC deals (<10 vs. ~100), and the proportion of corporate-sponsored R&D (25% vs. 70-90%). The density of technology companies in Houston was far lower than the leading regions, so we had an underdeveloped infrastructure to support startups and a small pool of startup leaders.

Still, the city’s leaders wanted to see biotechnology become a major driver for growth in Houston’s economy over the next 15-20 years by creating 65,000 to 95,000 jobs and allowing Houston to remain competitive. Two organizations in town, the Houston Technology Center and BioHouston, lead the city’s efforts to encourage growth in the biotechnology sector. These organizations deserve credit for more than doubling the number of life sciences companies in Houston, as well as tripling life sciences employment.

But Houston still lags far behind the major biotech clusters. What is missing? For a while, the prevailing reason was that there just wasn’t enough biotech-savvy venture capital in town. Startups were forced to seek funding on the West or East coasts, and those deals invariably required the startup to move away from Houston.

This is only one piece of the puzzle, however.

Results of a competitive analysis

Last spring, I led a team of Rice EMBA students in an analysis of Houston’s biotech cluster. Our analysis included a look at the best practices of Houston’s competitors with the goal of identifying opportunities. The 20 competitors we considered were a selection of universities, economic development organizations (EDOs), non-profits, startup incubators, and state programs.

For each of the competitors, we examined their organizational philosophy and vision, primary target audience, scale, activities, and fundraising model. For the universities, we found extensive cross-campus programs with strong ties to the local business community. The schools actively promote technology transfer to students, postdocs, and faculty through a variety of cross disciplinary events designed to encourage attendees to think about how research can be commercialized. The integration of technology transfer with research stood out at UCSF, in particular, where the Center for BioEntrepreneurship is officially housed in the Office of Research. Similar initiatives to link academic research and local industry were found at the EDOs, non-profits, and state programs, with the additional focus on developing biotechnology-friendly public policy. Continue reading ‘Houston’s Dearth of Biotech Entrepreneurship’

Mar26th2008

Life Sciences Entrepreneurial Management Certificate Program

The Houston area is emerging as a center for the life sciences industry. Numerous start-up companies have emerged in pharmaceuticals, biotechnology, medical devices, and telemedicine. This is generating a demand for leaders with a background in both entrepreneurship and the life sciences. To educate these leaders, Rice University Executive Education, the Rice Alliance for Technology and Entrepreneurship, and BioHouston have collaborated to offer the Life Sciences Entrepreneurial Management Certificate. Participants will learn about market opportunities, intellectual property issues, life science business plans, sources of funding, and the successful launch and management of a life science start-up.

Registration:
General Registrants ($995)–Register Online
Members of Houston Academic Institutions ($500)–To register, please contact the Registrar at 713-348-6060

Course Schedule: Spring 2008
Unit 1: Understanding the Life Science Industry and Business Environment

Module 1 Overview of the Biotech/Pharmaceutical & Medical Device Industry  
Module 2 Understanding the Regulatory Process of FDA  
Module 3 Understanding Intellectual Property Protection and Licensing  
Module 4 Assessing the Market Opportunity  

Unit 2: Business Strategy and Planning in Life Science Entrepreneurship

Module 5 Business Strategy and Planning  
Module 6 Communicating Your Plan  
Module 7 Sources of Funding  

Unit 3: Company Formation in Life Science Entrepreneurship

Module 8 Issues and Strategies in Forming a Company  
Module 9 Management, Corporate Governance & Human Resources  
Module 10 Issues in Growth, Sales and Exit Strategies  
Module 11 Elevator Pitches  

Participants will receive admission to the 7th Annual Rice Alliance Life Science Technology Forum on May 15, 2008.

Feb27th2008

BioHouston Chili Cook-Off

Join over 500 of your friends and colleagues for a day of networking and fun at the 2008 Chili Cook-Off. Our Chili Cook-Off is more than just chili - it brings the attendees together as a life science community.

All individuals welcome - team participation is not required to enjoy the chili. With door prizes, activities, networking, and CHILI, this is an event not to be missed!

Chili Cook-Off Individual Registrations: All registrations close Tuesday, March 25th
Individual Ticket–BioHouston Members ($25)
Individual Ticket–Non-Members ($35)

Chili Cook-Off Team Registrations: Team registrations close Thursday, March 20th–all teams must be pre-registered to participate
Team Sign-Up ($125 + $25 Per Team Member)

Door prize and sponsorship opportunities available…please contact Lauren Stroman at 713-979-9106. Don’t miss this opportunity to promote your company and join your fellow supporters of the biotech industry.

Sponsorships still available include:
Key-Ring Bottle Openers
Mints
Caricature Artist
Relaxation Tent

Current Chili Cook-Off sponsors:
Encysive Pharmaceuticals, Inc. - Entertainment
Ernst & Young LLP - Aprons
Fairway Medical Technologies - Koozies
FKP Architects
- Food & Beer Tent
Introgen Therapeutics - Caps
InVentiv Clinical - Cups
Lexicon Pharmaceuticals, Inc. - Registration Tent
Vaughn Construction - Potholders

Feb7th2008

Rice Alliance hosts largest Business Plan Competition in the World

rice_alliance_logo_1.jpg

The Rice Alliance has gone and outdone themselves again by nearly doubling the amount of funds that will be awarded at this year’s Business Plan Competition.  They will be awarding over $600,000 dollars in funds for approximately 36 different graduate teams from around the world, which enables them to lay claim to hosting “the largest and richest intercollegiate MBA/graduate-level business plan competition in the world, with more prize money, more teams competing, and more judges than any other competition.”  (Somebody please tell me they are videotaping this thing, because I think this would make a great reality show).  Also, according to their web site, every team will receive some type of cash award so noone goes home empty handed. 

Are you a graduate team with a killer business plan?  You can still register your team by submitting your executive summary before February 21st here and you can find all of the complete details about the event here.

Dec17th2007

Santé Ventures Raises $130 Million Debut Healthcare Venture Fund

Santé Ventures

Santé Ventures, an Austin based venture capital group focused on medical technology, health services and health care IT raised $130 million for its debut fund. Although the fund is new, the group has been investing in companies for some time now. Santé is not stranger to Houston having invested in two local companies: Tyrell and Intercede Health.

Dec7th2007

Getting Serious About Gaming

Playnormous
CBS Channel 11 News KHOU - TV aired a story last night on the use of video games for serious purposes. Archimage was featured as an innovative Houston-based company that is creating video games designed to improve the health of children, specifically obesity and type 2 diabetes prevention.

Archimage’s president, Richard Buday, was interviewed along with two of their partners, Dr. Tom Baranowski of Baylor College of Medicine CNRC and Dr. Cliff Dacso of the Abramson Center for the Future of Health. Several clips were shown from Archimiage’s two NIH-funded role-playing video game adventures in healthy eating and exercise, Escape from Diab and Nanoswarm: Invasion from Inner Space.

Archimage is the parent company of a Houston startup, Playnormous. You may recall Jerald Reichstein from Archimage presented Playnormous at the Rice Alliance 5th Annual IT and Web 2.0 Venture Forum (which we covered here and here). If you did not get a chance to attend the event, you can watch Reichstein’s presentation here courtesy of the BusinessMakers Radio Show.

What I love most about serious games for health is that it brings several Houston specialties, life science and IT, together to address a burgeoning and under served market. As a parent, I also like the opportunity to have my kids play something other than Barbie and Nickelodeon (I also eagerly await Konstruction Zone’s launch).

DISCLOSURE: Playnormous is a client of Mosaic CFO, a financial advisory firm owned by Josh Tabin.

Nov3rd2007

Interview with Walter Ulrich, President and CEO of the Houston Technology Center

When I first met Walter Ulrich at a Houston Technology Center event, what I gathered most about him was that this guy was the real deal: a true “pocket protector” geek in the most admiring sense of the word. Ulrich has been a pioneer in the information technology sector for almost 40 years. In the 1970’s, Ulrich led the development of the first commercially successful email service. That’s impressive.
During the 1980’s and 1990’s, Ulrich consulted with Fortune 100 company’s on technology and business issues until he became the CEO of Houston-based Mincron Software Systems. After leaving that role, Ulrich was one of two Houston technology professionals to be appointed by Texas Gov. Rick Perry to serve on the advisory committee for the $200 million Emerging Technology Fund.

I had a chance to catch up with Walter this last week; here are some excerpts from our chat:

Josh: I know that you have been in and around technology for many years. How did you come to get involved with the HTC?

Walter: The HTC looked like a place where I could give back as a volunteer, and it turned out to also be the place where much important business goes on.  As someone active in the technology world, active and deep participation in the HTC was not only personally satisfying but it is good for business.

Josh: There are all different perspectives on the HTC’s core mission. How would you characterize your vision?

Walter: We aspire to make Houston a globally recognized center of technology innovation and commercialization, particularly focused on IT and Web 2.0, energy and clean energy technologies, bio/life sciences, nanotechnology and NASA-related aerospace. We have the underlying economic strength and have been building the business infrastructure over the last ten years.  Now it is time to execute successful commercialization by driving successes one emerging company at a time.

Josh: There are many groups around town that all seem to overlap in different respects when it comes to supporting technology development and new business creation (Rice Alliance for Technology and Entrepreneurship, University of Houston Small Business Development Center, HTC, Greater Houston Partnership, Mayor’s Office). From an outsiders perspective, there does not seem to be much collaborative effort among these groups. Is this the case and if so, what can be done to have a more concerted effort to work together? Continue reading ‘Interview with Walter Ulrich, President and CEO of the Houston Technology Center’

Sep27th2007

5th Annual Rice Alliance Energy & Clean Technology Venture Forum Today

Today is the 5th Annual Rice Alliance Energy & Clean Technology Venture Forum held at the Jones School (McNair Hall) , Rice University. Here is an overview of the event:

  • One of the largest energy venture forums in North America
  • Emerging energy technology companies will showcase their new ventures in front of an audience of 400-500 investors and venture capitalists, industry representatives, business leaders, advisors/mentors, service providers
  • Several keynote speakers will share their insights
  • 45-60 companies will give an elevator pitch
  • 5 companies will present their business plans
  • 35-40 companies will participate in the Technology Company Showcase.
  • Plus, learn how major oil companies and venture capitalists make decisions to invest in early stage technology companies

If you get a chance to make it today, say hello to Kurt Stoll who is there today.